Welcome to the Holiday Inn Portsmouth The hotel is conveniently located on the Ohio River in the downtown business area. Within walking distance to Boney fiddle Historic District and its collection of antique shops. Guests can enjoy visiting a variety of popular attractions near our hotel. Portsmouth, Ohio offers a charming downtown district with many restaurants and is home to Shawnee State University, The Vern Riffe Center for the Arts, and our famous Floodwall Murals.